A6770

A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase[1][2].

Product Specifications

CAS Number

[1331754-16-5]

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/a6770.html

Purity

99.0

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

CC(C1=NC=C(CO)N1)=O

Molecular Formula

C6H8N2O2

Molecular Weight

140.14

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Mamoru Ohtoyo, et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. Lipids. 2016 Oct;51 (10) :1207-1216.|[2]Mamoru Ohtoyo, et al. Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. Cell Chem Biol. 2016 May 19;23 (5) :555-560.