Phospho-CBL (Tyr774) Recombinant Antibody, Biotin Conjugated
Product Specifications
Background
Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome.
Synonyms
Casitas B lineage lymphoma proto oncogene; CBL2; E3 ubiquitin protein ligase CBL; Oncogene CBL2; Proto oncogene c CBL; RING finger protein 55; RNF55; Signal transduction protein CBL.
Gene ID
867
Swiss Prot
P22681
Modification Site
Tyr774
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human
Target
CBL (Tyr774)
Clonality
Recombinant
Conjugation
Biotin
Source
KLH conjugated synthetic peptide derived from human CBL around the phosphorylation site of Y774
Applications
WB, IHC-P, IHC-F
Purification
Purified Polyclonal A
Concentration
Lot dependent
Dilution
WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
867
Isotype
IgG
Curated Selection
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