Argonaute 3/eIF2C3 Recombinant Antibody, HRP Conjugated
Product Specifications
Background
Required for RNA-mediated gene silencing (RNAi) . Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.
Synonyms
EIF2C3; Argonaute3; Argonaute 3; AGO3; EIF-2C 3; HAgo3; EIF2C 3; Protein argonaute-3.
Gene ID
192669
Swiss Prot
Q9H9G7
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Argonaute 3/eIF2C3
Clonality
Recombinant
Conjugation
HRP
Source
KLH conjugated synthetic peptide derived from human eIF2C3
Applications
WB
Purification
Purified by Protein A.
Concentration
Lot dependent
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
192669
Isotype
IgG
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