Smac Recombinant Antibody, AbBy Fluor™ 594 Conjugated
Product Specifications
Background
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) . Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Synonyms
SMAC; DFNA64; DIABLO; SMAC3.
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Smac
Clonality
Recombinant
Conjugation
AbBy Fluor™ 594
Source
KLH conjugated synthetic peptide derived from human DIABLO
Applications
WB, IF, Flow-Cyt
Purification
Purified by Protein A.
Excitation Emission
590nm/617nm
Concentration
Lot dependent
Dilution
WB (1:300-5000), IF (), Flow-Cyt (1ug/Test)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Isotype
IgG
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6199580-01 0.1 mL
ARFIP1 (Arfaptin-1, ADP-ribosylation Factor-interacting Protein 1) (MaxLight 490)
Ask
View Details 
MBS6199580-02 5x 0.1 mL
ARFIP1 (Arfaptin-1, ADP-ribosylation Factor-interacting Protein 1) (MaxLight 490)
Ask
View Details 
243233-AP 100 µL
AKT3 (v-akt murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, gamma), DKFZp434N0250, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2) (AP) discontinued
Ask
View Details 