VUF10166
Product Specifications
UNSPSC Description
VUF10166 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB). VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 μM[1].
Target Antigen
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vuf10166.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1CCN(C2=NC3=CC=CC=C3N=C2Cl)CC1
Molecular Weight
262.744
References & Citations
[1]Thompson AJ, et al. VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors. J Pharmacol Exp Ther. 2012 May;341(2):350-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100552/VUF10166-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100552/VUF10166-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
155584-74-0
Available Sizes
Curated Selection
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