Phospho-beta Arrestin 1 (Ser412) Recombinant Antibody, PE-Cy5 Conjugated
Product Specifications
Background
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation.
Synonyms
ARB1; ARR1; ARRB1; Arrestin 2; Arrestin beta 1.
Gene ID
408
Swiss Prot
P49407
Modification Site
Ser412
Cellular Locus
Cytoplasm, Nucleus, Cell membrane
Host
Rabbit
Cross Reactivity
Human
Target
Beta Arrestin 1
Clonality
Recombinant
Conjugation
PE-Cy5
Source
KLH conjugated synthetic peptide derived from human beta Arrestin 1 around the phosphorylation site of S412
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
488nm/670nm
Concentration
Lot dependent
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
408
Isotype
IgG
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