Biotinylated-JQ1
Biotinylated-JQ1 (Biotin-JQ1) is a biotinylated derivative of JQ1 with high affinity for the bromodomain of BRD4. Biotinylated-JQ1 inhibits MM1.S multiple myeloma cells proliferation with the EC50 of 0.4 μM[1].
Product Specifications
CAS Number
1635437-52-3
Product Name Alternative
Biotin-JQ1
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/biotinylated-jq1.html
Purity
99.33
Solubility
DMSO : 180 mg/mL (ultrasonic)
Smiles
CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(NCCCOCCOCCOCCCNC(CCCC[C@H]4[C@]5([H])[C@](NC(N5)=O)([H])CS4)=O)=O)C6=NN=C(C)N26
Molecular Formula
C39H53ClN8O6S2
Molecular Weight
829.47
References & Citations
[1]Lars Anders, et al. Genome-wide localization of small molecules. Nat Biotechnol. 2014 Jan;32 (1) :92-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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