Desmocollin 3 Recombinant Antibody, APC Conjugated
Product Specifications
Background
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Synonyms
Desmocollin-3; DSC3_HUMAN; Cadherin family member 3; Desmocollin-4; HT-CP; CDHF3; DSC4
Gene ID
1825
Swiss Prot
Q14574
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Mouse, Rat
Target
Desmocollin?3
Clonality
Recombinant
Conjugation
APC
Source
KLH conjugated synthetic peptide derived from human Desmocollin 3
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
650nm/660nm
Concentration
Lot dependent
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Human
Gene ID URL
1825
Isotype
IgG
Curated Selection
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