Phospho-Girdin (Tyr1765) Recombinant Antibody
Product Specifications
Background
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K) -dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Synonyms
GIV (pY1765) ; Girdin (phospho Y1765) ; p-Girdin (phospho Y1765) ; Akt phosphorylation enhancer; APE; Coiled coil domain containing protein 88A; G alpha interacting vesicle associated protein; Girders of actin filament; GIV; HkRP1; Hook related protein 1; AKT iphosphorylation enhancer; Akt phosphorylation enhancer; Ccdc88a; GIV; GRDN; GRDN_HUMAN; HkRP1; Hook related protein 1; Hook-related protein 1; KIAA1212.
Gene ID
55704
Swiss Prot
Q3V6T2
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Target
Phospho-Girdin (Tyr1765)
Clonality
Recombinant
Conjugation
Unconjugated
Source
KLH conjugated synthesised phosphopeptide derived from human APE around the phosphorylation site of Ser1765
Applications
IHC-P, IHC-F, IF
Purification
Purified by Protein A.
Concentration
1mg/ml
Dilution
IHC-P (IHC-P=1:200-500), IHC-F (1:100-500), IF ()
Buffer
0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Prediction Reactivity
Human, Mouse, Rat
Gene ID URL
55704
Isotype
IgG
Curated Selection
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