Phospho-MLKL (Ser345) Recombinant Antibody
Product Specifications
Background
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Synonyms
Phospho-MLKL (S345) ; pMLKL Ser345; Mixed lineage kinase domain-like protein, Mlkl
Gene ID
74568
Swiss Prot
Q9D2Y4
Modification Site
Ser345
Host
Rabbit
Cross Reactivity
Mouse
Target
Phospho-MLKL (Ser345)
Clonality
Recombinant
Conjugation
Unconjugated
Source
Synthetic phospho-peptide corresponding to residues surrounding Ser345 of human MLKL
Applications
WB, IP, ICC/IF
Purification
Purified by Protein A.
Concentration
Lot dependent
Dilution
WB (1:300-5000), IP (1-2ug), ICC/IF (1:50-100)
Buffer
0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
Modification
Phosphorylation
Storage Conditions
Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
74568
Isotype
IgG
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