AHR Recombinant Antibody
Product Specifications
Background
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates (PubMed:10395741, PubMed:28602820, PubMed:7961644, PubMed:23275542, PubMed:30373764) . Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644) . Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644) . Involved in cell-cycle regulation (PubMed:12213388) . Likely to play an important role in the development and maturation of many tissues (PubMed:12213388) . Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820) . Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820) .
Synonyms
Class E basic helix-loop-helix protein 76, Ah receptor, AhR, bHLHe76
Gene ID
196
Swiss Prot
P35869
Host
Rabbit
Cross Reactivity
Human, Mouse
Target
AHR
Clonality
Recombinant
Conjugation
Unconjugated
Source
Human Aryl hydrocarbon Receptor aa 600-800
Applications
WB, IHC-P, IF (ICC)
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
WB (1:300-5000), IHC-P (1:200-400), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
196
Isotype
IgG
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
128807-ML550 100 µL
KIAA1967 (DBIRD Complex Subunit KIAA1967, Deleted in Breast Cancer Gene 1 Protein, DBC-1, DBC.1, p30 DBC, DBC1) (MaxLight 550)
Ask
View Details