TFRC Recombinant Antibody, Cy5 Conjugated
Product Specifications
Background
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Synonyms
Transferrin receptor protein 1, T9, p90, CD_antigen: CD71, TR, TfR, TfR1, Trfr, TFRC
Gene ID
P02786
Swiss Prot
P02786
Host
Rabbit
Cross Reactivity
Human, Rat
Target
TFRC
Clonality
Recombinant
Conjugation
Cy5
Source
Human Transferrin Receptor between 100 to 450 amino acids
Applications
WB, Flow-Cyt
Purification
Purified by Protein A.
Excitation Emission
625,650nm/670nm
Concentration
Lot dependent
Dilution
WB (1:300-5000), Flow-Cyt (1ug/Test)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Mouse
Gene ID URL
P02786
Isotype
IgG
Curated Selection
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