TFRC Recombinant Antibody
Product Specifications
Background
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Synonyms
Transferrin receptor protein 1, T9, p90, CD_antigen: CD71, TR, TfR, TfR1, Trfr, TFRC
Gene ID
P02786
Swiss Prot
P02786
Host
Rabbit
Cross Reactivity
Human, Rat
Target
TFRC
Clonality
Recombinant
Conjugation
Unconjugated
Source
Human Transferrin Receptor between 100 to 450 amino acids
Applications
WB, Flow-Cyt, ICC/IF
Purification
Purified by Protein A.
Concentration
Lot dependent
Dilution
WB (1:300-5000), Flow-Cyt (1ug/Test), ICC/IF (1:50-100)
Buffer
0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Prediction Reactivity
Mouse
Gene ID URL
P02786
Isotype
IgG
Curated Selection
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