Caspase-9 Recombinant Antibody
Product Specifications
Background
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly (ADP-ribose) polymerase (PARP) . Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Synonyms
Caspase-9, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, ICE-like apoptotic protease 6, CASP-9, APAF-3, ICE-LAP6, CASP9
Swiss Prot
P55211
Host
Rabbit
Cross Reactivity
Human, Mouse
Target
Caspase-9
Clonality
Recombinant
Conjugation
Unconjugated
Source
Human Caspase-9 aa 200-350
Applications
WB, IHC-P, IHC-F, IF
Purification
Purified by Protein A.
Concentration
Lot dependent
Dilution
WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500), IF ()
Buffer
0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
Modification
Unmodified
Storage Conditions
Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Isotype
IgG
Curated Selection
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