Phospho-Tau (Thr231) Recombinant Antibody
Product Specifications
Background
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Synonyms
Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT
Gene ID
4137
Swiss Prot
P10636
Modification Site
Thr231
Host
Rabbit
Cross Reactivity
Mouse, Rat
Target
Phospho-Tau (Thr231)
Clonality
Recombinant
Conjugation
Unconjugated
Source
Synthetic phospho-peptide surrounding Thr231 of human Tau
Applications
WB
Purification
Purified by Protein A.
Concentration
Lot dependent
Dilution
WB (1:300-5000)
Buffer
0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Prediction Reactivity
Human
Gene ID URL
4137
Isotype
IgG
Curated Selection
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