ERK1/2 Recombinant Antibody, PE-Cy5 Conjugated
Product Specifications
Background
P44/42 MAP Kinase (Thr202) ; ERK (extracellular signal regulated kinase), also known as MAPK (mitogen activated protein kinase) has two closely related isoforms of 44 kDa and 42 kDa, respectively. These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli including mitogens, hormones, growth factors, cytokines, and bioactive peptides. Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth and differentiation as well as the cytoskeleton. ERK1 and ERK2 are phosphorylated within the activation loop on both a Threonine and a Tyrosine residue (within a Thr-Glu-Tyr motif) by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of ERK1&2.
Synonyms
ERK 1; ERK 2; ERK-2; ERK1; erk1/2; ERK2; ERT1; ERT2; Extracellular signalregulated kinase 1; Extracellular signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAP kinase isoform p44; MAPK 1; MAPK 2; MAPK 3; Mapk1; MAPK2; MAPK3; Mitogen-activated protein kinase 1; Mitogenactivated protein kinase 2; MK01_HUMAN; p38; p40; p41; p42-MAPK; PRKM 2
Swiss Prot
P27361, P28482
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
ERK1/2
Clonality
Recombinant
Conjugation
PE-Cy5
Source
Recombinant Human ERK1 + ERK2 between 150 amino acids to C-terminus
Applications
WB, Flow-Cyt
Purification
Purified by Protein A.
Excitation Emission
488nm/670nm
Concentration
Lot dependent
Dilution
WB (1:300-5000), Flow-Cyt (1ug/Test)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Isotype
IgG
Curated Selection
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