Beclin 1 Monoclonal Antibody, Biotin Conjugated
Product Specifications
Background
Plays a central role in autophagy (PubMed:23184933) . Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530) . Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521) . Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397) . May play a role in antiviral host defense. Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
Synonyms
Beclin-1; BECN1; Coiled-coil myosin-like BCL2-interacting protein; Protein GT197
Gene ID
8678
Swiss Prot
Q14457
Host
Mouse
Cross Reactivity
Human, Mouse, Rat
Target
Beclin 1
Clonality
Monoclonal
Clone
7B12
Conjugation
Biotin
Source
KLH conjugated synthetic peptide derived from human Beclin 1
Applications
WB, IHC-P
Purification
Purified by Protein G.
Concentration
1ug/ul
Dilution
WB (1:300-5000), IHC-P (1:200-400)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
8678
Isotype
IgG
Curated Selection
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