Amastatin (hydrochloride)

Amastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with Ki values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase[1].

Product Specifications

CAS Number

[100938-10-1]

Product Name Alternative

(Z)-Mutagenic Impurity of Tenofovir Disoproxil

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Aminopeptidase; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/amastatin-hydrochloride.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C(O)C[C@@H](C(O)=O)NC([C@H](C(C)C)NC([C@H](C(C)C)NC([C@@H](O)[C@H](N)CC(C)C)=O)=O)=O.[H]Cl

Molecular Formula

C21H39ClN4O8

Molecular Weight

511.01

Precautions

H315, H319, H335

References & Citations

[1]S H Wilkes, et al. The Slow, Tight Binding of Bestatin and Amastatin to Aminopeptidases. J Biol Chem. 1985 Oct 25;260 (24) :13154-62.|[2]J J Millership, et al. In Vitro and in Vivo Evaluation of Aminopeptidase Inhibitors as Antimicrosporidial Therapies. J Eukaryot Microbiol. 2001; Suppl:95S-98S.