TNF alpha Monoclonal Antibody
Product Specifications
Background
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
Synonyms
DIF; TNFA; TNFSF2; TNF-alpha; Tumor necrosis factor; Cachectin; Tumor necrosis factor ligand superfamily member 2; TNF-a; TNF
Gene ID
7124
Swiss Prot
P01375
Cellular Locus
Secreted, Membrane bound
Host
Mouse
Cross Reactivity
Human
Immunogen
77-233/233
Target
TNF alpha (1F6)
Clonality
Monoclonal
Clone
1F6
Conjugation
Unconjugated
Source
This antibody is produced using full length recombinant human TNF-alpha.
Applications
WB, IHC-P, IF (IHC-P)
Purification
Purified by Protein G.
Concentration
1ug/ul
Dilution
WB (1:300-5000), IHC-P (1:200-400), IF (IHC-P) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Specificity
This antibody is produced using full length recombinant TNF-alpha protein.
Gene ID URL
7124
Isotype
IgG
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