CACNA1S Polyclonal Antibody, Cy7 Conjugated
Product Specifications
Background
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA) . They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA) . Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
Synonyms
Voltage-dependent L-type calcium channel subunit alpha-1S; Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; Voltage-gated calcium channel subunit alpha Cav1.1; CACNA1S; CACH1; CACN1; CACNL1A3
Gene ID
779
Swiss Prot
Q13698
Cellular Locus
Extracellular
Host
Rabbit
Cross Reactivity
Mouse, Rat
Immunogen
901-1000/1873
Target
CACNA1S
Clonality
Polyclonal
Conjugation
Cy7
Source
KLH conjugated synthetic peptide derived from human CACNA1S
Applications
IF (IHC-P), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
743nm/767nm
Concentration
1ug/ul
Dilution
IF (IHC-P) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Human, Cow, Pig, Rabbit
Gene ID URL
779
Isotype
IgG
Curated Selection
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