IACS-9571 (hydrochloride)

IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively[1].

Product Specifications

CAS Number

[2319611-93-1]

Product Name Alternative

ASIS-P040 (hydrochloride)

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/IACS-9571_Hydrochloride.html

Purity

98.27

Solubility

DMSO : 125 mg/mL (ultrasonic; warming) |H2O : 10 mg/mL (ultrasonic)

Smiles

[H]Cl.O=S(C1=CC=C(OC)C(OC)=C1)(NC2=C(OC3=CC(OCCC)=CC(OCCCCN(C)C)=C3)C=C(N4C)C(N(C)C4=O)=C2)=O

Molecular Formula

C32H43ClN4O8S

Molecular Weight

679.22

References & Citations

[1]Palmer WS, et al. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25;59 (4) :1440-54.