ZNRF3 Polyclonal Antibody, AbBy Fluor™ 488 Conjugated
Product Specifications
Background
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.
Synonyms
RNF203; BK747E2.3; E3 ubiquitin-protein ligase ZNRF3; RING finger protein 203; Zinc/RING finger protein 3; ZNRF3; KIAA1133
Gene ID
84133
Swiss Prot
Q9ULT6
Cellular Locus
Extracellular
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
101-200/936
Target
ZNRF3
Clonality
Polyclonal
Conjugation
AbBy Fluor™ 488
Source
KLH conjugated synthetic peptide derived from human ZNRF3
Applications
WB, IF
Purification
Purified by Protein A.
Excitation Emission
499nm/519nm
Concentration
1ug/ul
Dilution
WB (WB=1:500-2000), IF (IF=1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
84133
Isotype
IgG
Curated Selection
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