ZNRF3 Polyclonal Antibody, AbBy Fluor™ 350 Conjugated

Product Specifications

Background

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.

Synonyms

RNF203; BK747E2.3; E3 ubiquitin-protein ligase ZNRF3; RING finger protein 203; Zinc/RING finger protein 3; ZNRF3; KIAA1133

Gene ID

84133

Swiss Prot

Q9ULT6

Cellular Locus

Extracellular

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Immunogen

101-200/936

Target

ZNRF3

Clonality

Polyclonal

Conjugation

AbBy Fluor™ 350

Source

KLH conjugated synthetic peptide derived from human ZNRF3

Applications

WB, IF

Purification

Purified by Protein A.

Excitation Emission

346nm/442nm

Concentration

1ug/ul

Dilution

WB (WB=1:500-2000), IF (IF=1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

84133

Isotype

IgG

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