KIAA1199 Polyclonal Antibody, AbBy Fluor™ 350 Conjugated

Product Specifications

Background

Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.

Synonyms

CCSP1; TMEM2L; KIAA1199; Cell migration-inducing and hyaluronan-binding protein; CEMIP; HYBID

Gene ID

57214

Swiss Prot

Q8WUJ3

Cellular Locus

Cytoplasm, Nucleus, Secreted, Cell membrane, Extracellular matrix

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Immunogen

101-200/1361

Target

KIAA1199

Clonality

Polyclonal

Conjugation

AbBy Fluor™ 350

Source

KLH conjugated synthetic peptide derived from human TMEM2L

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

346nm/442nm

Concentration

1ug/ul

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Prediction Reactivity

Dog, Cow, Horse, Chicken, Rabbit

Gene ID URL

57214

Isotype

IgG

Curated Selection

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