TRP12/TRPV4 Polyclonal Antibody, PE Conjugated
Product Specifications
Background
Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca (2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca (2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
Synonyms
SMAL; VRL2; BCYM3; CMT2C; SPSMA; TRP12; VROAC; HMSN2C; OTRPC4; SSQTL1; Transient receptor potential cation channel subfamily V member 4; TrpV4; Osm-9-like TRP channel 4; Transient receptor potential protein 12; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; VRL-2; Vanilloid receptor-related osmotically-activated channel; VR-OAC
Gene ID
59341
Swiss Prot
Q9HBA0
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Bovine
Immunogen
301-400/871
Target
TRP12/TRPV4
Clonality
Polyclonal
Conjugation
PE
Source
KLH conjugated synthetic peptide derived from human TRPV4
Applications
FCM, IF, Flow-Cyt
Purification
Purified by Protein A.
Excitation Emission
496,564nm/578nm
Concentration
1ug/ul
Dilution
FCM (1:20-100), IF (), Flow-Cyt (1ug/Test)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Mouse, Rat, Dog, Cow, Pig, Chicken
Gene ID URL
59341
Isotype
IgG
Curated Selection
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