Nicastrin Polyclonal Antibody
Product Specifications
Background
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) . It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Synonyms
ATAG1874; Nicastrin; NCSTN; KIAA0253; UNQ1874/PRO4317
Gene ID
23385
Swiss Prot
Q92542
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
21-120/709
Target
Nicastrin
Clonality
Polyclonal
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Nicastrin
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Prediction Reactivity
Mouse, Rat, Cow, Pig, Horse, Chicken
Gene ID URL
23385
Isotype
IgG
Curated Selection
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