A 438079
Product Specifications
UNSPSC Description
A 438079 is a potent, and selective?P2X7 receptor?antagonist with?pIC50?of 6.9.
Target Antigen
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a-438079.html
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : 0.2 mg/mL (ultrasonic)
Smiles
ClC1=C(Cl)C(C2=NN=NN2CC3=CC=CN=C3)=CC=C1
Molecular Weight
306.15
References & Citations
[1]McGaraughty S, et al. P2X7-related modulation of pathological nociception in rats. Neuroscience. 2007 Jun 8;146(4):1817-28.|[2]Mesuret G, et al. CNS Neurosci Ther. 2014 Jun;20(6):556-64.|[3]Marcellino D, et al. On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079. J Neural Transm (Vienna). 2010 Jun;117(6):681-7.|[4]Martins JP, et al. The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice. Br J Pharmacol. 2012 Jan;165(1):183-96.Brain, Behavior, and Immunity. 2020 Aug;88:507-514.|Front Mol Neurosci. 2018 Nov 6;11:401.|Gen Physiol Biophys. 2019 Sep;38(5):407-416.|Inflammation. 2024 Aug 17.|Int J Mol Sci. 2022 May 17;23(10):5586.|J Adv Res. 2024 Jul 15:S2090-1232(24)00298-4.|Med Sci Monit. 2020 Sep 21;26:e925491. |Neural Regen Res. 2021 Aug;16(8):1582-1591.|Purinergic Signal. 2023 Mar 1.|Cancer Immunol Res. 2020 Nov;8(11):1426-1439.|J Ethnopharmacol. 2024 Sep 7:118792.|J Immunol. 2023 May 5;ji2200838.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15488/A-438079-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15488/A-438079-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
899507-36-9
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1131670-01 0.02 mg (E-Coli)
Recombinant Sulfolobus islandicus Chromatin protein Cren7 (creN7)
Ask
View Details MBS1131670-02 0.1 mg (E-Coli)
Recombinant Sulfolobus islandicus Chromatin protein Cren7 (creN7)
Ask
View Details