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Phospho-Alpha synuclein (Ser129) Polyclonal Antibody

Product Specifications

Background

The synucleins, including Alpha-synuclein (also designated NACP for nonamyloid component precursor), Beta-synuclein (also designated PNP 14 for neuroprotein 14) and Gamma-synuclein (also designated persyn or BCSG1 for breast cancer-specific gene 1) are presynaptic protein abundant in neurons. Alpha-synuclein, a component of Alzheimer?s disease amyloid plaques, is localized to neuronal cell bodies and synapses. Coordinate expression of Alpha-synucleinand Beta-synuclein may be important during hematopoetic cell differentiation. In patients with Parkinson?s disease, a mutant form of Alpha-synuclein has been found and Gamma-synuclein is associated with axonal pathology.

Synonyms

SNCAphospho S129; alpha Synuclein phospho S129 ; alpha-Synuclein Ser129; Synuclein alphaSer129; Alpha synuclein; Alpha-Synuclein; Alpha-synuclein, isoform NACP140; alpha SYN; MGC105443; MGC110988; MGC127560; MGC64356; NACP; Non A beta component of AD amyloid; Non A4 component of amyloid precursor; Non-A-beta component of alzheimers disease amyloid , precursor of; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; PARK 1; PARK 4; PARK1; PARK4; Parkinson disease autosomal dominant, Lewy body 4; Parkinson disease familial 1; PD 1; PD1; Syn; SNCA; Snca synuclein, alpha non A4 component of amyloid precursor; SYUA_HUMAN; Synuclein alpha; Synuclein, alpha non A4 component of amyloid precursor

Gene ID

6622

Modification Site

Ser129

Cellular Locus

Cytoplasm, Nucleus, Cell membrane

Host

Rabbit

Cross Reactivity

Human

Target

Phospho-Alpha synuclein (Ser129)

Clonality

Polyclonal

Conjugation

Unconjugated

Source

KLH conjugated synthetic phosphopeptide derived from human SNCA around the phosphorylation site of Ser129 [MP (p-S) EE]

Applications

WB, ELISA, FCM, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1ug/ul

Dilution

WB (1:300-5000), ELISA (1:500-1000), FCM (1:20-100), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Gene ID URL

6622

Isotype

IgG

Curated Selection

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