Phospho-Bcl-xL (Thr115) Polyclonal Antibody, PE-Cy7 Conjugated
Product Specifications
Background
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X (L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F (1) F (0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. Isoform Bcl-X (S) promotes apoptosis.
Synonyms
BCLX; BCL2L; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; PPP1R52; BCL-XL/S; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X; BCL2L1
Gene ID
598
Swiss Prot
Q07817
Modification Site
Thr115
Cellular Locus
Cytoplasm, Nucleus, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Phospho-Bcl-xL (Thr115)
Clonality
Polyclonal
Conjugation
PE-Cy7
Source
KLH conjugated synthetic phosphopeptide derived from human BCL2L1 around the phosphorylation site of Thr115
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
488nm/780nm
Concentration
1ug/ul
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Dog, Cow, Sheep, Pig, Horse
Gene ID URL
598
Isotype
IgG
Curated Selection
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