DUB-IN-2
DUB-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8[1].
Product Specifications
CAS Number
924296-19-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/DUBs-IN-2.html
Purity
99.62
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
N#CC1=C(C#N)N=C2C(/C(C3=C2C=CC=C3)=N/OCC)=N1
Molecular Formula
C15H9N5O
Molecular Weight
275.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5 (4) :552-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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