Phospho-PPAR alpha (Ser12) Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC) . Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Synonyms
PPAR; NR1C1; hPPAR; PPARalpha; Peroxisome proliferator-activated receptor alpha; PPAR-alpha; Nuclear receptor subfamily 1 group C member 1; PPARA
Gene ID
5465
Swiss Prot
Q07869
Modification Site
Ser12
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat, Rabbit
Target
Phospho-PPAR alpha (Ser12)
Clonality
Polyclonal
Conjugation
Biotin
Source
KLH conjugated synthetic phosphopeptide derived from human PPAR alpha around the phosphorylation site of ser12
Applications
WB, ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Prediction Reactivity
Dog, Cow, Pig, Horse, GuineaPig
Gene ID URL
5465
Isotype
IgG
Curated Selection
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385057 100 µg
PIK3CA (PI 3 Kinase Catalytic Subunit Alpha, Phosphoinositide 3 Kinase Catalytic Alpha Polypeptide, PI3 Kinase p110 Subunit Alpha, PtdIns 3 Kinase p110, PtdIns 3 Kinase Regulatory Subunit Alpha, Phosphatidylinositol 3 Kinase Regulatory Subunit Polypeptide 1, GRB1, PtdIns 3 Kinase Subunit p110 Alpha, Phosphoinositide 3 Kinase Regulatory Subunit 1 (Alpha), PtdIns-3-Kinase Subunit p110-Alpha, PtdIns-3-Kinase Subunit Alpha, PtdIns 3 Kinase Regulatory Subunit p85 Alpha, p110alpha, Phosphatidylinositol 4 5 Bisphosphate 3 Kinase Catalytic Subunit Alpha Isoform, Phosphatidylinositol 3 Kinase Regulatory 1, Phosphatidylinositol 4 5 Bisphosphate 3 Kinase 110kD Catalytic Subunit Alpha, PIK3R1, EC:2.7.11.1, Phosphoinositide-3-Kinase Catalytic Alpha Polypeptide, PI3K Alpha, PI3-Kinase Subunit Alpha, Phosphatidylinositol 3 Kinase Catalytic Alpha Polypeptide, p110 Alpha, Phosphatidylinositol 3 Kinase Regulatory Subunit Alpha, Phosphatidylinositol 3 Kinase Catalytic 110kD Alpha, 5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform, PI3K-Alpha, PI3 Kinase Subunit Alpha, MGC142163, EC:2.7.1.153, PI3 Kinase Regulatory Subunit Alpha, p85 Alpha, PI3Kalpha, Phosphoinositide 3 Kinase Regulatory Subunit 1, MGC142161, Serine/Threonine Protein Kinase PIK3CA (EC:2.7.11.1), 5-Bisphosphate 3-Kinase 110kD Catalytic Subunit Alpha, PI3K, Phosphatidylinositol 3 Kinase Associated p 85 Alpha, p85, Phosphatidylinositol 3 Kinase 85kD Regulatory Subunit Alpha, Phosphatidylinositol 4, PI3K Regulatory Subunit Alpha, PI3 Kinase Subunit p85 Alpha, PIK3CA, PtdIns 3 Kinase Subunit Alpha)
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