FBP1 Polyclonal Antibody, AbBy Fluor™ 555 Conjugated

Product Specifications

Background

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

Synonyms

FBP; Fructose-1,6-bisphosphatase 1; FBPase 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Liver FBPase; FBP1

Gene ID

2203

Swiss Prot

P09467

Cellular Locus

Cytoplasm, Nucleus, Extracellular matrix

Host

Rabbit

Cross Reactivity

Human, Rat

Immunogen

31-130/338

Target

FBP1

Clonality

Polyclonal

Conjugation

AbBy Fluor™ 555

Source

KLH conjugated synthetic peptide derived from human FBP1

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

553nm/568nm

Concentration

1ug/ul

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Prediction Reactivity

Mouse, Dog, Cow, Sheep, Pig, Horse, Chicken, Rabbit

Gene ID URL

2203

Isotype

IgG

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