Aspartate aminotransferase Antibody

Product Specifications

Background

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H (2) S via the action of 3-mercaptopyruvate sulfurtransferase (3MST) . Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

Synonyms

CCAT; GIG18; cAspAT; ASTQTL1; Aspartate aminotransferase, cytoplasmic; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; Glutamate oxaloacetate transaminase 1; Transaminase A; GOT1

Gene ID

2805

Swiss Prot

P17174

Cellular Locus

Cytoplasm

Host

Rabbit

Cross Reactivity

Mouse

Immunogen

301-400/413

Target

Aspartate Aminotransferase, Cytoplasmic

Clonality

Polyclonal

Conjugation

Unconjugated

Source

KLH conjugated synthetic peptide derived from human Aspartate aminotransferase, cytoplasmic

Applications

WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1ug/ul

Dilution

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Specificity

This antibody is specific for cytoplasmic Aspartate Aminotransferase, and will not detect the mitochondrial form.

Prediction Reactivity

Human, Rat, Dog, Cow, Pig, Rabbit

Gene ID URL

2805

Isotype

IgG

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