Legumain Polyclonal Antibody
Product Specifications
Background
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity) . May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
Synonyms
AEP; LGMN1; PRSC1; Legumain; Asparaginyl endopeptidase; Protease, cysteine 1; LGMN
Gene ID
5641
Swiss Prot
Q99538
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
201-300/433
Target
Legumain
Clonality
Polyclonal
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Legumain
Applications
WB, IHC-P, IHC-F, IF, Flow-Cyt
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
WB (WB=1:500-2000), IHC-P (IHC-P=1:100-500), IHC-F (IHC-F=1:100-500), IF (IF=1:100-500), Flow-Cyt (Flow-Cyt=3ug/Test)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Prediction Reactivity
Dog, Cow, Horse
Gene ID URL
5641
Isotype
IgG
Curated Selection
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