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CGMP Polyclonal Antibody, AbBy Fluor™ 647 Conjugated

Product Specifications

Background

Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP. Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC) . Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG) .

Synonyms

Cyclic GMP; Cyclic guanosine monophosphate; Guanosine 3 5 Cyclic Monophosphate.

Host

Rabbit

Cross Reactivity

Others

Target

CGMP

Clonality

Polyclonal

Conjugation

AbBy Fluor™ 647

Source

OVA conjugated cGMP

Applications

IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

650nm/665nm

Concentration

1ug/ul

Dilution

IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Specificity

Due to the fact that BSA is used as the carrier, this antibody will cross-react with Albumin.

Isotype

IgG

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