6-Bromo-2-hydroxy-3-methoxybenzaldehyde

6-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC95682) (Compound 3-5) is a selective and potent IRE-1α inhibitor with an IC50 value of 0.08 μM. 6-Bromo-2-hydroxy-3-methoxybenzaldehyde can be used for research on diseases associated with the unfolded protein response (UPR), such as cancer and autoimmune diseases[1].

Product Specifications

CAS Number

[20035-41-0]

Product Name Alternative

NSC95682

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

IRE1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/NSC95682.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=CC1=C(C(OC)=CC=C1Br)O

Molecular Formula

C8H7BrO3

Molecular Weight

231.04

Precautions

H315, H319, H335

References & Citations

[1]John Bruce Patterson, et al. Ire-1a inhibitors. WO2008154484A1. 2008-12-18.|[2]Lasák, et al. Synthesis, bacteriostatic and anticancer activity of novel phenanthridines structurally similar to benzo [c] phenanthridine alkaloids. Molecules 23.9 (2018) : 2155.