Perfluoroundecanoic acid
Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS) . Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation[1][2][3][4].
Product Specifications
CAS Number
[2058-94-8]
UNSPSC
12352211
Hazard Statement
H302+H332, H351, H360, H362, H372
Target
Akt; Arginase; Atg8/LC3; Autophagy; Biochemical Assay Reagents; ERK; mTOR; p62; TGF-beta/Smad; Wnt; β-catenin
Type
Reference compound
Related Pathways
Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Purity
99.85
Solubility
DMSO : 200 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)F)F)F)F)F)F)O
Molecular Formula
C11HF21O2
Molecular Weight
564.09
Precautions
H302+H332, H351, H360, H362, H372
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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