HBEGF Polyclonal Antibody
Product Specifications
Background
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Synonyms
DTR; DTS; DTSF; HEGFL; Proheparin-binding EGF-like growth factor; HBEGF
Gene ID
1839
Swiss Prot
Q99075
Cellular Locus
Secreted, Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
51-150/208
Target
HBEGF
Clonality
Polyclonal
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human HB-EGF/DTSF
Applications
ELISA, IHC-P, IF (ICC)
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Prediction Reactivity
Mouse, Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit
Gene ID URL
1839
Isotype
IgG
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