Phospho-Stat2 (Tyr690) Polyclonal Antibody, HRP Conjugated
Product Specifications
Background
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Synonyms
P113; ISGF-3; STAT113; Signal transducer and activator of transcription 2; STAT2
Gene ID
6773
Swiss Prot
P52630
Modification Site
Tyr690
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Mouse
Target
Phospho-Stat2 (Tyr690)
Clonality
Polyclonal
Conjugation
HRP
Source
KLH conjugated synthetic phosphopeptide derived from human Stat2 around the phosphorylation site of Tyr690
Applications
WB, ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Specificity
This phosphorylation site is homologous to that of Tyr689 in Mouse and Tyr690 in Rat.
Prediction Reactivity
Human, Rat, Dog, Horse
Gene ID URL
6773
Isotype
IgG
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