Phospho-PFKFB3/PFK2 (Ser467) Polyclonal Antibody, AbBy Fluor™ 405 Conjugated
Product Specifications
Background
6 Phosphofructo 2 Kinase plays a role in the synthesis and degradation of fructose 2,6-bisphosphate. Fructose-2,6-bisphosphate acts as an allosteric regulator of 6-phosphofructo-1-kinase (PFK1), which catalyses a key step in the glycoytic pathway. Glycolytic flux is key to tumour growth, and small molecule inhibition of 6 Phosphofructo 2 Kinase suppresses both glycolytic flux and tumour growth. Several lines of evidence suggest that 6 Phosphofructo 2 Kinase is also involved in obesity.
Synonyms
PFK2; IPFK2; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; 6PF-2-K/Fru-2,6-P2ase 3; PFK/FBPase 3; 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; Renal carcinoma antigen NY-REN-56; iPFK-2; PFKFB3
Gene ID
5209
Swiss Prot
Q16875
Modification Site
Ser467
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Phospho-PFKFB3/PFK2 (Ser467)
Clonality
Polyclonal
Conjugation
AbBy Fluor™ 405
Source
KLH conjugated synthetic phosphopeptide derived from human PFK2 around the phosphorylation site of Ser467
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
401nm/421nm
Concentration
1ug/ul
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Specificity
This phosphorylated site is homologous to that of Ser467 in Mouse and Ser496 in Rat.
Prediction Reactivity
Cow, Pig, Horse, Chicken, Rabbit
Gene ID URL
5209
Isotype
IgG
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