Phospho-PERK (Thr980) Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR) -induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) . Involved in control of mitochondrial morphology and function.
Synonyms
Pek; Perk; AI427929; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; Eif2ak3
Gene ID
13666
Swiss Prot
Q9Z2B5
Modification Site
Thr980
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Phospho-PERK (Thr980)
Clonality
Polyclonal
Conjugation
Biotin
Source
KLH conjugated synthetic phosphopeptide derived from mouse PERK around the phosphorylation site of Thr980
Applications
WB, ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Prediction Reactivity
Dog, Cow, Pig, Rabbit
Gene ID URL
13666
Isotype
IgG
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