Phospho-Numb (Ser276) Polyclonal Antibody, APC Conjugated

Product Specifications

Background

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

Synonyms

S171; C14orf41; c14_5527; Protein numb homolog; h-Numb; Protein S171; NUMB

Gene ID

8650

Swiss Prot

P49757

Modification Site

Ser276

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Target

Phospho-Numb (Ser276)

Clonality

Polyclonal

Conjugation

APC

Source

KLH conjugated synthetic phosphopeptide derived from human Numb around the phosphorylation site of Ser276

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

650nm/660nm

Concentration

1ug/ul

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Specificity

This phosphorylation site is homologous to that of Ser276 in Mouse and Ser275 in Rat.

Prediction Reactivity

Dog, Cow, Sheep, Pig, Horse, Chicken, Rabbit

Gene ID URL

8650

Isotype

IgG

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