Phospho-NF2 (Ser518) Polyclonal Antibody

Product Specifications

Background

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Synonyms

ACN; SCH; BANF; Merlin; Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin; NF2

Gene ID

4771

Swiss Prot

P35240

Modification Site

Ser518

Cellular Locus

Cytoplasm, Nucleus, Cell membrane

Host

Rabbit

Cross Reactivity

Mouse, Rat

Target

Phospho-NF2 (Ser518)

Clonality

Polyclonal

Conjugation

Unconjugated

Source

KLH conjugated synthetic phosphopeptide derived from human Merlin around the phosphorylation site of Ser518

Applications

WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1ug/ul

Dilution

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Prediction Reactivity

Human, Dog, Cow, Pig, Horse, Chicken, Rabbit

Gene ID URL

4771

Isotype

IgG

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

abx906888-01 15 nmol

Mouse ADORA2B siRNA

Ask

View Details

abx906888-02 30 nmol

Mouse ADORA2B siRNA

Ask

View Details

MBS8296210-01 10 nmol

mmu-miR-3475-3p miRNA Inhibitor

Ask

View Details

MBS8296210-02 20 nmol

mmu-miR-3475-3p miRNA Inhibitor

Ask

View Details

MBS8296210-03 5x 20 nmol

mmu-miR-3475-3p miRNA Inhibitor

Ask

View Details

CF502795 100 µg

PDLIM2 Mouse Monoclonal Antibody [Clone ID: OTI14D9]

Ask

View Details