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Phospho-MEF2A (Ser408) Polyclonal Antibody, Cy3 Conjugated

Product Specifications

Background

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT] (4) TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.

Synonyms

Mef2; ADCAD1; RSRFC4; RSRFC9; Myocyte-specific enhancer factor 2A; Serum response factor-like protein 1; MEF2A

Gene ID

4205

Swiss Prot

Q02078

Modification Site

Ser408

Cellular Locus

Nucleus

Host

Rabbit

Cross Reactivity

Mouse, Rat

Target

Phospho-MEF2A (Ser408)

Clonality

Polyclonal

Conjugation

Cy3

Source

KLH conjugated synthetic phosphopeptide derived from human MEF2A around the phosphorylation site of Ser408

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

512,550nm/570,615nm

Concentration

1ug/ul

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.biossantibodies.com/datasheets/bs-3268R-Cy3

Prediction Reactivity

Human

Gene ID URL

4205

Isotype

IgG

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