Phospho-LRP6 (Ser1490) Polyclonal Antibody, PE Conjugated
Product Specifications
Background
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity) .
Synonyms
ADCAD2; Low-density lipoprotein receptor-related protein 6; LRP-6; LRP6
Gene ID
4040
Swiss Prot
O75581
Modification Site
Ser1490
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Rat
Target
Phospho-LRP6 (Ser1490)
Clonality
Polyclonal
Conjugation
PE
Source
KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
496,564nm/578nm
Concentration
1ug/ul
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Mouse, Dog, Cow, Pig, Horse, Chicken
Gene ID URL
4040
Isotype
IgG
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