Phospho-MCSF Receptor (Tyr723) Polyclonal Antibody, PE-Cy5 Conjugated
Product Specifications
Background
This protein tyrosine kinase transmembrane receptor is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a member of the CSF1/PDGF receptor family of tyrosine protein kinases and contains 5 immunoglobulin like C2 type domains. CD115 is expressed by cells of the monocytic lineage and by progenitor cells. Mutations in this gene have been associated with a predisposition to myeloid malignancy.
Synonyms
FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; Proto-oncogene c-Fms; CSF1R
Gene ID
1436
Swiss Prot
P07333
Modification Site
Tyr723
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human
Target
Phospho-MCSF Receptor (Tyr723)
Clonality
Polyclonal
Conjugation
PE-Cy5
Source
KLH conjugated synthetic phosphopeptide derived from human CSF1R around the phosphorylation site of tyrosine 723
Applications
WB, FCM
Purification
Purified by Protein A.
Excitation Emission
488nm/670nm
Concentration
1ug/ul
Dilution
WB (1:300-5000), FCM (1:20-100)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Mouse, Rat, Dog, Cow, Horse
Gene ID URL
1436
Isotype
IgG
Curated Selection
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