Phospho-Bcl-2 (Ser70) Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) .
Synonyms
Bcl-2; Apoptosis regulator Bcl-2; Bcl2
Gene ID
24224
Swiss Prot
P49950
Modification Site
Ser70
Cellular Locus
Cytoplasm, Nucleus, Cell membrane
Host
Rabbit
Cross Reactivity
Human
Target
Phospho-Bcl-2 (Ser70)
Clonality
Polyclonal
Conjugation
Biotin
Source
KLH conjugated synthetic phosphopeptide derived from rat Bcl-2 around the phosphorylation site of Ser70
Applications
WB, ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Prediction Reactivity
Mouse, Rat, Dog, Rabbit
Gene ID URL
24224
Isotype
IgG
Curated Selection
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