Phospho-Bax (Ser184) Polyclonal Antibody, AbBy Fluor™ 647 Conjugated
Product Specifications
Background
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Synonyms
BCL2L4; Apoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4; BAX
Gene ID
581
Swiss Prot
Q07812
Modification Site
Ser184
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Phospho-Bax (Ser184)
Clonality
Polyclonal
Conjugation
AbBy Fluor™ 647
Source
KLH conjugated synthetic phosphopeptide derived from human Bax around the phosphorylation site of Ser184
Applications
WB, IF
Purification
Purified by Protein A.
Excitation Emission
650nm/665nm
Concentration
1ug/ul
Dilution
WB (1:300-5000), IF ()
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Prediction Reactivity
Dog, Cow, Sheep, Pig
Gene ID URL
581
Isotype
IgG
Curated Selection
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