TNFR1 Polyclonal Antibody, AbBy Fluor™ 680 Conjugated

Product Specifications

Background

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

Synonyms

Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD120a; TNFRSF1A; TNFAR; TNFR1

Gene ID

7132

Swiss Prot

P19438

Cellular Locus

Secreted, Cell membrane

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Immunogen

1-100/455

Target

TNFR1

Clonality

Polyclonal

Conjugation

AbBy Fluor™ 680

Source

KLH conjugated synthetic peptide derived from human TNF Receptor I

Applications

WB, FCM, IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

679nm/702nm

Concentration

1ug/ul

Dilution

WB (1:300-5000), FCM (1:20-100), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Specificity

This antibody will recognize Isoform 1, 4 and 5, but not Isoform 2 or 3.

Prediction Reactivity

Dog, Cow, Pig, Horse, Rabbit

Gene ID URL

7132

Isotype

IgG

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