CENPA Polyclonal Antibody
Product Specifications
Background
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro) .
Synonyms
CenH3; CENP-A; Histone H3-like centromeric protein A; Centromere autoantigen A; Centromere protein A; CENPA
Gene ID
1058
Swiss Prot
P49450
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
65-140/140
Target
CENPA
Clonality
Polyclonal
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human CENPA
Applications
ELISA, IHC-P, IHC-F, IF, Flow-Cyt
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
ELISA (ELISA=1:5000-10000), IHC-P (IHC-P=1:100-500), IHC-F (IHC-F=1:100-500), IF (IF=1:100-500), Flow-Cyt (Flow-Cyt=1ug/Test)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
1058
Isotype
IgG
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